by Ken Chiacchia | Jun 8, 2023 | Anton 2, Science Highlights
Snapshot of the β2AR–Gs system: NE(+)-bound β2AR coupled with Gs protein. Different subunits and loops are illustrated by different colors (Green – β2AR, Gray – intracellular loop 3 or ICL3, Pink – GsαAH domain, Red – GsαRas domain, Blue – Gβ, Yellow – Gγ). From Y....
by Ken Chiacchia | Mar 1, 2023 | Anton 2, Science Highlights
Comparison of where D-serine (D-Ser, teal dots) and glutamate (Glu, gray dots) stick to the GluN2AA subunit. From Remy A Yovanno Tsung Han Chou Sarah J Brantley Hiro Furukawa Albert Y Lau (2022) Excitatory and inhibitory D-serine binding to the NMDA receptor eLife...
by Ken Chiacchia | Jan 18, 2023 | Anton 2, Bridges-2, Science Highlights
Different numbers of kinks in the iGlu-R protein from glutamate binding to the outside of channel cause its central pore (seen from the top looking down) to open progressively, allowing different levels of ion current to pass through. From Yelshanskaya, M.V., Patel,...
by Ken Chiacchia | Mar 23, 2022 | Anton 2, Science Highlights
anton 2 sims suggest how fish oil health benefits start at cell membrane Molecular simulations coupled with AI analysis reveal how omega-3 polyunsaturated fatty acids may regulate the size of membrane “rafts” The omega-3 polyunsaturated fatty acids...
by Ken Chiacchia | Sep 27, 2021 | Anton 2, Science Highlights
Anton 2 Simulations Explain mechanism for Loading DNA into Virus Two-phase Motor Packages DNA into Viral Capsids, May Offer Drug Target To cause disease, viruses must package their DNA into new virus particles to infect more cells. An important step—and...
by Ken Chiacchia | Apr 10, 2017 | Anton 2, Features
Anton 2 Supercomputer Operational at PSC Anton 2, a specialized supercomputer developed by D. E. Shaw Research that simulates the motions of biomolecules, has replaced the original Anton 1 system previously at PSC. The new machine, operationally supported through a...
