A common way for proteins to hold themselves together is with disulfide bridges. But scientists don’t completely understand why some proteins need them to “hook up” their structure. Researchers used the DESRES Anton system hosted at PSC to discover the critical role disulfides play in holding together MCoTI-II, a natural pesticide that would fall apart without disulfide bridges.
While diabetes poses many life- and limb-threatening problems, it also causes serious changes and problems in the digestive tract. A study using PSC’s Bridges system sifted through the DNA of thousands of microbe species in the healthy and diabetic intestines to learn how to help reduce digestive symptoms—and maybe even slow the course of the disease.