This issue of PSC Science Highlights focuses first and foremost on what many of us have been focused on—the ongoing COVID-19 pandemic, and how we will save human lives and prevent hospitalizations and disability.

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Above: COVID protease with an inhibitor molecule (light blue) in the active site.

With the vaccines rolling out we are finally seeing the end of the tunnel. But the gains aren’t yet “baked in,” so it’s no time to ease off on the scientific quest to understand and counter this threat to health and safety. Carnegie Mellon University scientists employed the power of artificial intelligence (AI) on Bridges-AI to narrow a field of 5 billion drugs to find a handful with real potential for stopping the SARS-CoV-2 virus. Out in the boundaries of space, a team from West Virginia University used AI on the main Bridges platform to automate the search for fast-radio-burst candidates, so astronomers can obtain new and better data to explain these mysterious phenomena. Closer to home, a Northern Arizona University group used Bridges to create an online tool that can help companies, governments and even individual citizens track the movement of commodities as different as clean water, food, medications and fuel to determine the best way to make supplies more resilient to natural and man-made disasters. In recent news, PSC’s new Bridges-2 platform has entered “production operations,” open to researchers in all fields; and the revolutionary Neocortex AI system has begun early access by select scientists. This and more, in the Spring/Summer 2021 issue of PSC Science Highlights!