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HIV Protein Switch May Help Virus Squeeze into Host Cell Nucleus

HIV Protein Switch May Help Virus Squeeze into Host Cell Nucleus

by Ken Chiacchia | Feb 21, 2025 | Bridges-2, Science Highlights

The pointed end of HIV’s outer viral shell, its capsid, helps it squeeze into host cells’ nuclear pore. A team from Pitt has simulated the virus in PSC’s Bridges-2 to show how a twist in a critical protein may help it shoehorn in. Based on a figure from Yang DT et al....
Large-Scale Evolution Simulations on PSC’s Neocortex Tackle Questions about Hypermutator Evolution

Large-Scale Evolution Simulations on PSC’s Neocortex Tackle Questions about Hypermutator Evolution

by Ken Chiacchia | Feb 5, 2025 | Neocortex, Science Highlights

In real life, mutants can arise when their DNA changes to give them an advantage over the rest of the population. A team from the University of Michigan used simulations on PSC’s Neocortex to find out why beneficial mutants rarely come to dominate real...
Bridges-2 Simulations Show Impact of Rocket Exhaust Water on Moon’s Ice Reservoirs

Bridges-2 Simulations Show Impact of Rocket Exhaust Water on Moon’s Ice Reservoirs

by Ken Chiacchia | Jan 22, 2025 | Bridges-2, Science Highlights

A visualization of the Moon’s Clavius crater. Credit: NASA’s Scientific Visualization Studio. Visualizer Ernie Wright (USRA), Technical support Laurence Schuler (ADNET Systems, Inc.), Ian Jones (ADNET Systems, Inc.) Previous Missions Did Not Add...
Anton Studies Reveal Blood Vessel Response to Mechanical Force

Anton Studies Reveal Blood Vessel Response to Mechanical Force

by Ken Chiacchia | Jan 3, 2025 | Anton, Science Highlights

Generated models of the AT1 receptors taken from Supporting Information: Structural Rearrangement of the AT1 Receptor Modulated by Membrane Thickness and Tension, Figure S11.  G Protein-Coupled Receptor Triggered by Mechanical Tension as Well as Chemical Signals,...
PSC Interns to Represent U.S. at International Student Competition

PSC Interns to Represent U.S. at International Student Competition

by Ken Chiacchia | Dec 18, 2024 | Bridges-2, Intern news, News, Press release

Benchmark Beasts Team to Compete at ISC25 Conference in Hamburg, Germany A team of interns from the Pittsburgh Supercomputing Center has been selected to represent the United States next year at an international high performance computing (HPC) competition for...
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