Foreword from the Directors

Michael Levine and Ralph Roskies

Michael Levine and Ralph Roskies
PSC co-scientific directors.

Once again, we're pleased to highlight some of the remarkable scientific work at Pittsburgh Supercomputing Center and also to announce our partnership with David E. Shaw Research in making an innovative new system available to the U.S. biomedical research community (p. 4).

Our biomedical visualization experts, Art Wetzel and Greg Hood, this year fortuitously struck up collaboration with Clay Reid of Harvard, one of the leading visual cortex scientists in the world. When Reid began doing high-throughput transmission electron microscopy of the mouse visual cortex, he needed help assembling and processing massive amounts of imaging data. Wetzel and Hood and PSC's National Resource for Biomedical Supercomputing have proved to be the resource he needed, and it's a pleasure to be able to report on this work (p. 20).

Tom Cheatham at the University of Utah has grown up, scientifically speaking, with the NSF supercomputing centers program and, more recently, the TeraGrid (p. 5). He's pushed the limits of what's possible with molecular dynamics simulations for many years, and his current work with the RNA of the hepatitis C virus has potential for groundbreaking strides in new drug therapies for viral disease (p. 24).

Zulema Garraffo of the University of Miami has used PSC resources for several years to refine HYCOM, a state-of-the-art ocean model. She and her colleagues have shown the importance of high resolution in ocean modeling as it bears on some of the challenging scenarios about how climate-induced changes in the Gulf Stream could affect Northern Europe (p. 28).

Two Carnegie Mellon projects, led respectively by Alessandro Acquisti and Colin Morningstar, exemplify how high-performance computing opens doors to new understanding in very different fields — Internet privacy (p. 32) and quantum chromodynamics (p. 40).

With effective collaboration between experiment and computation, John Yates, Ken Jordan of the University of Pittsburgh and colleagues Peter Maksymovych and Dan Sorescu of the National Energy Technology Laboratory made new findings in the chemistry of molecular chain reactions (p. 36).

PSC continues to be a vital resource for research and education in Pennsylvania (p. 6) and, through the Super Computing Science Consortium (p. 8), we help to promote economic development in southwest Pennsylvania and West Virginia and important work on development of clean-fuel technologies. This year's publication features a new section (pp. 9-11) that highlights our important work within the community to help educate the next generation of scientists and science-literate citizens.

As always, this publication represents the work of PSC's staff, second-to-none as an assemblage of talent and experience in high-performance computing. We are grateful for support from the National Science Foundation, the U.S. Department of Energy, the National Institutes of Health, the Commonwealth of Pennsylvania and many others.