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My HMM makes lousy alignments!

See above.

Also, note that all the hmmt training methods suffer from local minima problems. If your model was produced by simulated annealing, try a few more independent annealing runs and save the model with the highest final score. Alternatively, try providing a (manual? structural? ClustalV?) alignment of a few of your sequences as a hint.



Sean Eddy
Mon Apr 17 09:54:19 CDT 1995